Three-dimensional model of surfactant replacement therapy
نویسندگان
چکیده
منابع مشابه
Three-dimensional model of surfactant replacement therapy.
Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respiratory distress syndrome (ARDS), early successes were followed by failures. This un...
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OBJECTIVE: To analyze and update information about surfactant therapy replacement in newborns with lung diseases. SOURCES: Literature review, including textbooks, meta-analyses, prospective, randomized controlled trials, retrospective assessments and case studies. Literature was reviewed based on the authors clinical and scientific experience regarding surfactant replacement therapy in neonatal...
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Surfactant deficiency at birth makes it difficult for the newborn to inflate its lungs. As the infant makes increasingly vigorous attempts to ventilate noncompliant lungs, delayed adsorption of lung fluid, pulmonary edema, extravasation of plasma proteins into air spaces, and lung injury occur, which cause progressive respiratory distress. Intratracheal administration of surfactant into the inf...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1504025112